Dr. Hamilton grew up in Columbia and graduated from the University of Missouri Kansas City School of Dentistry. Prior to studying at the University of Missouri Kansas City, he attended the University of Missouri, majoring in Biology. Dr. Hamilton joined his father Lanny Hamilton DDS and his aunt Rebecca Mathis in practice beginning in 1996. Since beginning his practice in dentistry, Dr. Hamilton keeps up to date through consistent continuing education and is a member of the Central Dental Society, the Missouri Dental Association, and the American Dental Association.

Drew and his wife Shari have one daughter, Kate. He also has three dogs, Daisy, Luna, and Millie. He enjoys coaching and playing soccer with his daughter.